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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GSK3B
All Species:
38.22
Human Site:
S417
Identified Species:
64.69
UniProt:
P49841
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49841
NP_001139628.1
420
46744
S417
N
A
A
S
A
S
A
S
N
S
T
_
_
_
_
Chimpanzee
Pan troglodytes
XP_001164371
420
46753
S417
N
A
A
S
A
S
A
S
N
S
T
_
_
_
_
Rhesus Macaque
Macaca mulatta
XP_001110547
420
46919
S417
N
A
A
S
A
S
A
S
N
S
T
_
_
_
_
Dog
Lupus familis
XP_856611
420
46696
S417
N
A
A
S
A
S
A
S
N
S
T
_
_
_
_
Cat
Felis silvestris
Mouse
Mus musculus
Q9WV60
420
46692
S417
N
A
A
S
A
S
A
S
N
S
T
_
_
_
_
Rat
Rattus norvegicus
P18266
420
46724
S417
N
A
A
S
A
S
A
S
N
S
T
_
_
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_416557
433
48108
S430
S
V
A
T
A
S
A
S
N
S
T
_
_
_
_
Frog
Xenopus laevis
NP_001083752
420
46885
S417
N
A
A
S
A
S
A
S
N
S
S
_
_
_
_
Zebra Danio
Brachydanio rerio
NP_571456
421
46854
S417
T
A
A
S
A
S
A
S
N
T
S
T
_
_
_
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P18431
1067
114422
S969
S
S
T
G
S
G
A
S
V
E
G
S
A
Q
P
Honey Bee
Apis mellifera
XP_392504
434
48445
T426
T
L
S
T
S
K
N
T
D
P
G
Q
S
S
M
Nematode Worm
Caenorhab. elegans
Q9U2Q9
362
40864
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8VZD5
410
46056
Baker's Yeast
Sacchar. cerevisiae
P38615
370
42986
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98
94.7
99.7
N.A.
99
98.8
N.A.
N.A.
93.7
93.3
95
N.A.
31.8
70.9
64.7
N.A.
Protein Similarity:
100
98.8
96.4
99.7
N.A.
99
99
N.A.
N.A.
95.1
97.1
97.1
N.A.
34.9
80.4
74.2
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
72.7
90.9
66.6
N.A.
13.3
0
0
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
90.9
100
83.3
N.A.
33.3
33.3
0
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
60.2
44.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
74
63.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
58
65
0
65
0
72
0
0
0
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
0
8
0
0
0
0
15
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
50
0
0
0
0
0
8
0
65
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
8
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
8
0
8
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
15
8
8
58
15
65
0
72
0
58
15
8
8
8
0
% S
% Thr:
15
0
8
15
0
0
0
8
0
8
50
8
0
0
0
% T
% Val:
0
8
0
0
0
0
0
0
8
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
58
65
65
65
% _